Does the center-of-mass restraints help in the case of docking protein pair with cross-link data?

HADDOCK
1

When i ran my case in the local version,i found the loose range of MS restraints will sometimes cause the protein pair part away very far. And when you narrow this range,the restraints will over-pull the the surface of the corresponding residue close and lead to the wrong orientation.Is there any good solution to this problem and is the local version of HADDOCK2.4 use the center-of-mass restraints by default?

Thanks a lot

2

Center of mass is never enabled by default

4

How to add the center of mass restraints in the local version of HADDOCK2.4?

5

Look for the cmrest parameter in run.cns