Z-score is zero

1

Hi, I run a protein ligand docking on haddock and this is the result I got.

  1. Z-score is returned as zero, does it mean the ligand does not bind to the protein?

  2. Also, is clustering 400 structures in 1 cluster incorrect?

HADDOCK clustered 400 structures in 1 cluster(s), which represents 100 % of the water-refined models HADDOCK generated. Note that currently the maximum number of models considered for clustering is 200.

Cluster 1

HADDOCK score -57.6 +/- 1.9
Cluster size 400
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RMSD from the overall lowest-energy structure 0.1 +/- 0.1
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Van der Waals energy -21.8 +/- 1.7
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Electrostatic energy -27.2 +/- 1.6
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Desolvation energy 2.9 +/- 2.5
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Restraints violation energy 1.2 +/- 0.1
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Buried Surface Area 568.4 +/- 9.0
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Z-Score 0.0
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2

Check the definition of the z-score. With one cluster by definition it is 0 - basic statistics

We should stop reporting it as it is not a metric that should be used.

3

Thank you for the clarification prof.Bonvin