Hi, I want to ask, for the active and passive residues, we need to predict those residues through our prediction/manually? before we submit to haddock ?
Yes - indeed
There are various ways of doing that using bioinformatics predictors, e.g. our own CPORT server:
https://milou.science.uu.nl/services/CPORT/
But many more options are possible
Can i ask if CPORT is suitable for detecting protein self-aggregation sites?
It seems from the literature that it is more suited for interactions such as enzyme-substrate or biochemical reactions.
Was wondering if CPORT can be applied for identifying IgG aggregation sites.
Thanks!
Well - it was never benchmarked for this. But you can try 