None of the active residues are accessible

Dear all, when I use HADDOCK for docking the interaction between a lipase and an inhibitor (small molecular), a problem emerged when I selected the active residues (144,168,231) of the protein (lipase). it showed :"None of the active residues are accessible”. What does this mean? How to solve it? help!

Well it means that your active residues are not accessible (they are buried).

You can turn off this option if you have an expert/guru level.