Docking refinement of multimeric structures

HADDOCK
1

I am trying to refine a complex that has 2 coupled proteins, the receptor (4 chains) and the ligand (5 chains). However, HADDOCK only provides the option to select 1 chain for each protein, so that I only get these 2 chains as a result in a PDB file and I require the complete model, that is, the 2 proteins with all their chains. I am following the protocol outlined at LightDock+HADDOCK membrane proteins tutorial – Bonvin Lab
Does anyone know if it is possible to do what I need?

Beforehand thank you very much,

Luciano

Talca, Chile

2

Try to submit the full model to the haddock2.4 refinement server.

https://wenmr.science.uu.nl/haddock2.4/refinement/1
3

Thank you very much, I will try and write here how it went!

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