The HADDOCK category is meant to discuss any HADDOCK-related issue. For general information about HADDOCK refer to HADDOCK – Bonvin Lab
I wanna ask a question. Is haddock score same with binding free energy? Because there is a journal that said “haddock score is sum of all energy that involved in the interaction”
It is not. Check the following papers for more info:
-
P.L. Kastritis and A.M.J.J. Bonvin Molecular origins of binding affinity: Seeking the Archimedean point. Curr. Opin. Struct. Biol., 23, 868-877 (2013).
-
P.L. Kastritis and A.M.J.J. Bonvin On the binding affinity of macromolecular interactions: daring to ask why proteins interact J. R. Soc. Interface, 10, doi: 10.1098/rsif.2012.0835 (2013).
-
P. Kastritis and A.M.J.J. Bonvin Are scoring functions in protein-protein docking ready to predict interactomes? Clues from a novel binding affinity benchmark. J. Proteome Research, 9, 2216-2225 (2010). See also the published correction
I wanna ask a question. Is haddock score same with binding free energy? Because there is a journal that said “haddock score is sum of all energy that involved in the interaction”
Sum of energy in not binding affinity…