ARCTIC-3d is not working

1

Hello, I have been trying to use ARCTIC-3D, but every time I try, I get an error message:

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command: arctic3d --full P06756 --threshold 0.866 --linkage_strategy average --int_cov_cutoff 0.7
exit status: 255
log:
[2026-02-04 23:06:19,391 cli INFO]
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ARCTIC-3D

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Starting ARCTIC-3D 0.4.1

[2026-02-04 23:06:19,391 output INFO] Creating output_directory arctic3d-P06756
[2026-02-04 23:06:19,392] cli.py:arctic3d:main:218: Target UNIPROTID: P06756
[2026-02-04 23:06:19,392] output.py:arctic3d.log:setup_output_folder:64: Setting up output folder arctic3d-P06756
[2026-02-04 23:06:27,411] interface.py:arctic3d.log:get_interface_residues:223: Could not make InterfaceResidues request for P06756, HTTPSConnectionPool(host=‘www.ebi.ac.uk’, port=443): Max retries exceeded with url: /pdbe/graph-api/uniprot/interface_residues/P06756 (Caused by NameResolutionError(“<urllib3.connection.HTTPSConnection object at 0x7ffeafe17850>: Failed to resolve ‘www.ebi.ac.uk’ ([Errno -3] Temporary failure in name resolution)”))
[2026-02-04 23:06:27,411] cli.py:arctic3d:main:255: Interface Residues: {}
[2026-02-04 23:06:27,411] cli.py:arctic3d:main:325: No interfaces found.
[2026-02-04 23:06:27,411] cli.py:arctic3d:main:327: arctic3d run completed in 8.02 seconds.

2

Command line version?

You seem to have a network issue looking at the log.

Did you try the web server?

3

That attempt was done on the web server, I apologize for not mentioning it

4

The server is functional - just tested with another protein. It seems your particular request fails.