Good day!
I am trying to dock the TRAIL ligand onto a trimer of Death Receptor 4. However, when I run the job onto the webserver, the results that I get are far from the experimental findings and have a positive HADDOCK score. Is there some way to set some restrains that the ligand would bind to the receptor in a fixed orientation? I have active sites in both receptor and ligand obtained from experimental studies.
Thank you!