How to choose a symmetry for a ab initio dimer docking?

HADDOCK
1

Hi,

I am trying to perform a ab-initio docking of a dimer but I do not know the kind of symmetry that it could have. Which selection of symmetry restraints would be the best then?

Thank you for your time.

2

If it is a homodimer, then I would expect then C2 symmetry

And also NCS symmetry between the chains.

Next to CM restraints

3

thank you for the answer. How many pairs of symmetry restraints would it be recommended to define for the homodimer?

4

Just one :slight_smile:

More would be redundant