Binding of all DNA strands to a specific region of protein

I have a major problem with DNA–protein docking. Different sequences of DNA, bind to a particular area of a protein even if these sequences do not look like each other. I examined 60 Aptamers including Lactate dehydrogenase and irrelevant DNA sequences so that all of the Aptamers bind to a specified area of LDH protein. This prediction is unacceptable in logical. Can you help me in this regard?