# The question about the file needed by haddock3 cfg file

**URL:** <https://ask.bioexcel.eu/t/the-question-about-the-file-needed-by-haddock3-cfg-file/5597>\
**Category:** HADDOCK\
**Created:** [April 14, 2025, 1:05am UTC](https://ask.bioexcel.eu/t/the-question-about-the-file-needed-by-haddock3-cfg-file/5597 "2025-04-14T01:05:19Z")\
**Posts on this page:** 3\
**Page:** 1

<div class="post-metadata">

**Author:** ![hf526235](https://avatars.discourse-cdn.com/v4/letter/h/b38774/32.png) [@hf526235](https://ask.bioexcel.eu/u/hf526235)\
**Post date:** [April 14, 2025, 1:05am UTC](https://ask.bioexcel.eu/t/the-question-about-the-file-needed-by-haddock3-cfg-file/5597/1 "2025-04-14T01:05:19Z")

</div>

Sorry to bother you , there is a question about how to generate the tbl,param and top file . As i checked the manual instruction and former question asked by others . Could i get tbl file by using restrain\_bodies.py script and using haddock 2.4/2.5 to get param and top file for the ligand ?

---

<div class="post-metadata">

**Author:** ![VGPReys](https://dub1.discourse-cdn.com/flex013/user_avatar/ask.bioexcel.eu/vgpreys/32/960_2.png) [@VGPReys](https://ask.bioexcel.eu/u/VGPReys)\
**Post date:** [April 14, 2025, 6:34am UTC](https://ask.bioexcel.eu/t/the-question-about-the-file-needed-by-haddock3-cfg-file/5597/2 "2025-04-14T06:34:15Z")

</div>

Dear skolae,

- the `restrain_bodies.py` script can indeed generate tbl files but it will contain only restraints keeping potential chain fragments / chain breaks in relative place to each other. To generate a actual ambiguous restraint file, I would suggest to use either [GenTBL webserver](https://wenmr.science.uu.nl/gentbl/), or the [`haddock-restraints` tool](https://github.com/haddocking/haddock-restraints).
- To generate parameters and topology files for ligands, there is currently no built in solution provided in **local** versions of the haddock2.X series. But we perform it on the fly when you use the webserver, when you are providing a ligand falling outside of the haddock library.

Cheers

---

<div class="post-metadata">

**Author:** ![hf526235](https://avatars.discourse-cdn.com/v4/letter/h/b38774/32.png) [@hf526235](https://ask.bioexcel.eu/u/hf526235)\
**Post date:** [April 14, 2025, 6:48am UTC](https://ask.bioexcel.eu/t/the-question-about-the-file-needed-by-haddock3-cfg-file/5597/3 "2025-04-14T06:48:59Z")

</div>

Dear Victor ，

Thank you for the response , it will be very helpful.

Best regards,

Huangfu Yifan

Victor Reys via BioExcel \<[notifications@bioexcel.discoursemail.com](mailto:notifications@bioexcel.discoursemail.com)\> 于2025年4月14日周一 15:44写道：