# Six molecule protein-protein docking using haddock

**URL:** https://ask.bioexcel.eu/t/six-molecule-protein-protein-docking-using-haddock/3317
**Category:** HADDOCK
**Created:** [October 31, 2021, 8:17pm UTC](https://ask.bioexcel.eu/t/six-molecule-protein-protein-docking-using-haddock/3317 "2021-10-31T20:17:51Z")
**Posts on this page:** 3
**Page:** 1

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### Author: ![Edumenezes](https://avatars.discourse-cdn.com/v4/letter/e/bc79bd/32.png) [@Edumenezes](https://ask.bioexcel.eu/u/Edumenezes)
#### Post date: [October 31, 2021, 8:17pm UTC](https://ask.bioexcel.eu/t/six-molecule-protein-protein-docking-using-haddock/3317/1 "2021-10-31T20:17:51Z")

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I’m trying to redock a structure that contains 6 chains.

and I’m having an error when inserting the active residues

the information I get is: You must supply either active and passive residues for both selections or for neither of them - Selections #1 and #3.

I input 6 molecules  
2 - light chain  
2- heavy chain  
2- from another

any idea where the error might be?

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### Author: ![amjjbonvin](https://dub1.discourse-cdn.com/flex013/user_avatar/ask.bioexcel.eu/amjjbonvin/32/23_2.png) [@amjjbonvin](https://ask.bioexcel.eu/u/amjjbonvin)
#### Post date: [October 31, 2021, 9:40pm UTC](https://ask.bioexcel.eu/t/six-molecule-protein-protein-docking-using-haddock/3317/2 "2021-10-31T21:40:27Z")

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Seems like a problem in the way you define your active and passive residues (as the error message is saying)

Also if I understand correctly you are docking two antibodies - doesn’t make sense to dock the chains separately. I would treat those as one molecule

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### Author: ![Edumenezes](https://avatars.discourse-cdn.com/v4/letter/e/bc79bd/32.png) [@Edumenezes](https://ask.bioexcel.eu/u/Edumenezes)
#### Post date: [November 22, 2021, 11:30pm UTC](https://ask.bioexcel.eu/t/six-molecule-protein-protein-docking-using-haddock/3317/3 "2021-11-22T23:30:26Z")

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thank you, now i realise it how to do that
