# Rigid Docking in Haddock 2.4

**URL:** https://ask.bioexcel.eu/t/rigid-docking-in-haddock-2-4/3410
**Category:** HADDOCK
**Created:** [January 15, 2022, 6:44pm UTC](https://ask.bioexcel.eu/t/rigid-docking-in-haddock-2-4/3410 "2022-01-15T18:44:01Z")
**Posts on this page:** 5
**Page:** 1

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### Author: ![Asathees](https://avatars.discourse-cdn.com/v4/letter/a/439d5e/32.png) [@Asathees](https://ask.bioexcel.eu/u/Asathees)
#### Post date: [January 15, 2022, 6:44pm UTC](https://ask.bioexcel.eu/t/rigid-docking-in-haddock-2-4/3410/1 "2022-01-15T18:44:01Z")

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Hi,

Apologies if this has been asked before but is there a protocol for rigid protein-ligand docking in Haddock 2.4?

Thanks

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### Author: ![amjjbonvin](https://dub1.discourse-cdn.com/flex013/user_avatar/ask.bioexcel.eu/amjjbonvin/32/23_2.png) [@amjjbonvin](https://ask.bioexcel.eu/u/amjjbonvin)
#### Post date: [January 15, 2022, 7:07pm UTC](https://ask.bioexcel.eu/t/rigid-docking-in-haddock-2-4/3410/2 "2022-01-15T19:07:33Z")

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Do you mean docking keeping both molecules rigid?

You can in the second submission tab on the server specific the flexibility treatment (semi-flexible segment) and define a molecule as rigid.

Further we have protein-ligand tutorials at:

[https://www.bonvinlab.org/education/HADDOCK24/](https://www.bonvinlab.org/education/HADDOCK24/)

with two ligand-related tutorials.

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### Author: ![Asathees](https://avatars.discourse-cdn.com/v4/letter/a/439d5e/32.png) [@Asathees](https://ask.bioexcel.eu/u/Asathees)
#### Post date: [January 15, 2022, 7:39pm UTC](https://ask.bioexcel.eu/t/rigid-docking-in-haddock-2-4/3410/3 "2022-01-15T19:39:13Z")

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Thanks for the quick response.

I am only trying to keep one of the ligands restrained but in regards to specifying the flexibility treatment of the molecule, the option to do so isn’t available to me.

Is this due to the access level on my profile, will I need a higher access level to use this option?

Thanks again

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### Author: ![amjjbonvin](https://dub1.discourse-cdn.com/flex013/user_avatar/ask.bioexcel.eu/amjjbonvin/32/23_2.png) [@amjjbonvin](https://ask.bioexcel.eu/u/amjjbonvin)
#### Post date: [January 15, 2022, 8:11pm UTC](https://ask.bioexcel.eu/t/rigid-docking-in-haddock-2-4/3410/4 "2022-01-15T20:11:29Z")

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Request higher level access via your registration page

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### Author: ![Asathees](https://avatars.discourse-cdn.com/v4/letter/a/439d5e/32.png) [@Asathees](https://ask.bioexcel.eu/u/Asathees)
#### Post date: [January 15, 2022, 8:28pm UTC](https://ask.bioexcel.eu/t/rigid-docking-in-haddock-2-4/3410/5 "2022-01-15T20:28:43Z")

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Request has been sent.

Thank you!