# Refinement on 2.2 after running 2.4?

**URL:** <https://ask.bioexcel.eu/t/refinement-on-2-2-after-running-2-4/2011>\
**Category:** HADDOCK\
**Created:** [May 12, 2020, 3:08pm UTC](https://ask.bioexcel.eu/t/refinement-on-2-2-after-running-2-4/2011 "2020-05-12T15:08:07Z")\
**Posts on this page:** 2\
**Page:** 1

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**Author:** ![jgibson\_rpi](https://avatars.discourse-cdn.com/v4/letter/j/71c47a/32.png) [@jgibson\_rpi](https://ask.bioexcel.eu/u/jgibson_rpi)\
**Post date:** [May 12, 2020, 3:08pm UTC](https://ask.bioexcel.eu/t/refinement-on-2-2-after-running-2-4/2011/1 "2020-05-12T15:08:07Z")

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Is it worth running a refinement on the refinement interface in HADDOCK 2.2 after running your docking through HADDOCK 2.4? Or is that already taken care of in the last part of HADDOCK 2.4?

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**Author:** ![amjjbonvin](https://dub1.discourse-cdn.com/flex013/user_avatar/ask.bioexcel.eu/amjjbonvin/32/23_2.png) [@amjjbonvin](https://ask.bioexcel.eu/u/amjjbonvin)\
**Post date:** [May 12, 2020, 3:30pm UTC](https://ask.bioexcel.eu/t/refinement-on-2-2-after-running-2-4/2011/2 "2020-05-12T15:30:59Z")

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In HADDOCK2.4 by default we don’t run the solvated refinement but only a minimisation.  
You can turn salvation.

Running an additional refinement through the server doesn’t make that much sense.  
But could be a way to get rid of the restraints energy. But clearly not the default.