# Refinement of haddock2.4 server

**URL:** <https://ask.bioexcel.eu/t/refinement-of-haddock2-4-server/4075>\
**Category:** HADDOCK\
**Created:** [January 13, 2023, 4:29am UTC](https://ask.bioexcel.eu/t/refinement-of-haddock2-4-server/4075 "2023-01-13T04:29:29Z")\
**Posts on this page:** 3\
**Page:** 1

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**Author:** ![LIU](https://avatars.discourse-cdn.com/v4/letter/l/a88e57/32.png) [@LIU](https://ask.bioexcel.eu/u/LIU)\
**Post date:** [January 13, 2023, 4:29am UTC](https://ask.bioexcel.eu/t/refinement-of-haddock2-4-server/4075/1 "2023-01-13T04:29:29Z")

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Dear all,

I have a quick question for the refinement.

I’m trying to do water refinement of my 10 models through the interface of Refinement on haddock2.4 server.

I also want to input some NOE distance restraints to do that, however, the Refinement interface does not has the options to add additional constraints for refinements.

Do you have any suggestions to do the water-refinement of the 10 models with NOEs through haddock2.4/2.2 server?

Thanks.  
CD

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**Author:** ![amjjbonvin](https://dub1.discourse-cdn.com/flex013/user_avatar/ask.bioexcel.eu/amjjbonvin/32/23_2.png) [@amjjbonvin](https://ask.bioexcel.eu/u/amjjbonvin)\
**Post date:** [January 13, 2023, 8:31am UTC](https://ask.bioexcel.eu/t/refinement-of-haddock2-4-server/4075/2 "2023-01-13T08:31:05Z")

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For this you will have to use the regular interface and follow the recipe described in: [Advanced refinement of molecular complexes – Bonvin Lab](https://www.bonvinlab.org/software/haddock2.4/tips/advanced_refinement/)

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**Author:** ![LIU](https://avatars.discourse-cdn.com/v4/letter/l/a88e57/32.png) [@LIU](https://ask.bioexcel.eu/u/LIU)\
**Post date:** [January 16, 2023, 3:49am UTC](https://ask.bioexcel.eu/t/refinement-of-haddock2-4-server/4075/3 "2023-01-16T03:49:49Z")

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It works, thanks.

Best  
CD