# ProdigyLigand interpretation for drug potential

**URL:** <https://ask.bioexcel.eu/t/prodigyligand-interpretation-for-drug-potential/3202>\
**Category:** PRODIGY\
**Created:** [August 13, 2021, 7:46am UTC](https://ask.bioexcel.eu/t/prodigyligand-interpretation-for-drug-potential/3202 "2021-08-13T07:46:37Z")\
**Posts on this page:** 3\
**Page:** 1

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**Author:** ![Syifa77](https://avatars.discourse-cdn.com/v4/letter/s/8c91f0/32.png) [@Syifa77](https://ask.bioexcel.eu/u/Syifa77)\
**Post date:** [August 13, 2021, 7:46am UTC](https://ask.bioexcel.eu/t/prodigyligand-interpretation-for-drug-potential/3202/1 "2021-08-13T07:46:37Z")

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Hi, I want to ask about the interpretation of delta G in prodigy-ligand, the output there are 2 kinds of delta G, predict and score. which one is represent a binding free energy of protein-ligand? if the both of them, why the different is so high? Thank you

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**Author:** ![amjjbonvin](https://dub1.discourse-cdn.com/flex013/user_avatar/ask.bioexcel.eu/amjjbonvin/32/23_2.png) [@amjjbonvin](https://ask.bioexcel.eu/u/amjjbonvin)\
**Post date:** [August 13, 2021, 9:08am UTC](https://ask.bioexcel.eu/t/prodigyligand-interpretation-for-drug-potential/3202/2 "2021-08-13T09:08:11Z")

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If you check the paper associated with the server you will see that the hgscore is meant to rank ligands while dGprediction is predicting the free energy of binding.

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**Author:** ![Syifa77](https://avatars.discourse-cdn.com/v4/letter/s/8c91f0/32.png) [@Syifa77](https://ask.bioexcel.eu/u/Syifa77)\
**Post date:** [August 13, 2021, 9:52am UTC](https://ask.bioexcel.eu/t/prodigyligand-interpretation-for-drug-potential/3202/3 "2021-08-13T09:52:07Z")

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okay thank you