# Prodigy del G and Kd values after Molecular Dynamics

**URL:** <https://ask.bioexcel.eu/t/prodigy-del-g-and-kd-values-after-molecular-dynamics/2339>\
**Category:** PRODIGY\
**Created:** [July 17, 2020, 3:37pm UTC](https://ask.bioexcel.eu/t/prodigy-del-g-and-kd-values-after-molecular-dynamics/2339 "2020-07-17T15:37:05Z")\
**Posts on this page:** 2\
**Page:** 1

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**Author:** ![amartya](https://avatars.discourse-cdn.com/v4/letter/a/f4b2a3/32.png) [@amartya](https://ask.bioexcel.eu/u/amartya)\
**Post date:** [July 17, 2020, 3:37pm UTC](https://ask.bioexcel.eu/t/prodigy-del-g-and-kd-values-after-molecular-dynamics/2339/1 "2020-07-17T15:37:05Z")

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Hello,

I was wondering how does del G and Kd values for a protein-protein complex change after simulating the complex. How comparable is Prodigy with MM-PBSA and MM-GBSA analysis of the same simulated complex?

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**Author:** ![amjjbonvin](https://dub1.discourse-cdn.com/flex013/user_avatar/ask.bioexcel.eu/amjjbonvin/32/23_2.png) [@amjjbonvin](https://ask.bioexcel.eu/u/amjjbonvin)\
**Post date:** [July 17, 2020, 4:03pm UTC](https://ask.bioexcel.eu/t/prodigy-del-g-and-kd-values-after-molecular-dynamics/2339/2 "2020-07-17T16:03:44Z")

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I don’t have the answer to this, but it would be nice if someone was to take the challenge and actually do the comparison on a large set of complexes…

It will take quite some more time than running PRODIGY 🙂