# Pmx analyse says "no good dgdl files provided"

**URL:** <https://ask.bioexcel.eu/t/pmx-analyse-says-no-good-dgdl-files-provided/5394>\
**Category:** pmx\
**Tags:** gromacs\
**Created:** [January 11, 2025, 11:32pm UTC](https://ask.bioexcel.eu/t/pmx-analyse-says-no-good-dgdl-files-provided/5394 "2025-01-11T23:32:39Z")\
**Posts on this page:** 3\
**Page:** 1

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**Author:** ![mukherjee175](https://avatars.discourse-cdn.com/v4/letter/m/ea5d25/32.png) [@mukherjee175](https://ask.bioexcel.eu/u/mukherjee175)\
**Post date:** [January 11, 2025, 11:32pm UTC](https://ask.bioexcel.eu/t/pmx-analyse-says-no-good-dgdl-files-provided/5394/1 "2025-01-11T23:32:39Z")

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I am working with a protein-peptide complex. I aim to do mutations on the peptide. I was performing mutation free energy calculations using the Fast growth method following the tutorial of the Trp cage. When I use pmx analyse to do the Free Energy estimation it gives me an error which says “no good dgdl files were provided”. Suspecting something wrong my files, I tried the calculation with the files from the tutorial and the problem still persists. Has anyone ever faced this problem? And how do I solve it? Any help would be much appreciated.  
A screenshot of the error is attached.

 ![image](https://europe1.discourse-cdn.com/flex013/uploads/bioexcel/original/2X/4/4294b341073e060bc061d9b84b7eb2121c072142.png)

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**Author:** ![Sudchem](https://avatars.discourse-cdn.com/v4/letter/s/ecccb3/32.png) [@Sudchem](https://ask.bioexcel.eu/u/Sudchem)\
**Post date:** [January 13, 2025, 8:39am UTC](https://ask.bioexcel.eu/t/pmx-analyse-says-no-good-dgdl-files-provided/5394/2 "2025-01-13T08:39:28Z")

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Hi,

If you are using pmx develop branch (installation: [pmx/tutorials/INSTALL at develop · deGrootLab/pmx · GitHub](https://github.com/deGrootLab/pmx/blob/develop/tutorials/INSTALL)) for the tutorial ([Mutation free energy calculations](http://pmx.mpibpc.mpg.de/summerSchool2020_tutorial1/index.html)), then either " pmx analyse -fA eqA/morphes/frame\*/dgdl.xvg -fB eqB/morphes/frame\*/dgdl.xvg -t 300 --nbins 25" or “./analyze\_dhdl.py -fA eqA/morphes/frame\*/dgdl.xvg -fB eqB/morphes/frame\*/dgdl.xvg -t 300 --nbins 25” should work fine (both of them work fine for me).

Could you please post the command you used, if the problem still persists?

All the best.

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<div class="post-metadata">

**Author:** ![mukherjee175](https://avatars.discourse-cdn.com/v4/letter/m/ea5d25/32.png) [@mukherjee175](https://ask.bioexcel.eu/u/mukherjee175)\
**Post date:** [January 13, 2025, 3:58pm UTC](https://ask.bioexcel.eu/t/pmx-analyse-says-no-good-dgdl-files-provided/5394/3 "2025-01-13T15:58:27Z")

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Hi,

Thank you for your reply. There was something wrong with my previous installation. I installed pmx again and it worked fine. And for reference I used  
pmx analyse -fA path\_to\_forward/frame\*/dgdl.xvg -fB path\_to\_backward/frame\*/dgdl.xvg -t 300 --nbins 25

Best,  
Shounak