# No correlation between score and binding affinity

**URL:** <https://ask.bioexcel.eu/t/no-correlation-between-score-and-binding-affinity/1699>\
**Category:** HADDOCK\
**Created:** [September 30, 2019, 7:07am UTC](https://ask.bioexcel.eu/t/no-correlation-between-score-and-binding-affinity/1699 "2019-09-30T07:07:12Z")\
**Posts on this page:** 3\
**Page:** 1

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**Author:** ![vafamayahi](https://avatars.discourse-cdn.com/v4/letter/v/f6c823/32.png) [@vafamayahi](https://ask.bioexcel.eu/u/vafamayahi)\
**Post date:** [September 30, 2019, 7:07am UTC](https://ask.bioexcel.eu/t/no-correlation-between-score-and-binding-affinity/1699/1 "2019-09-30T07:07:12Z")

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Hi,

I would like to know the titles of your published papers regarding that there is no correlation between haddock scores and binding affinity.

Best,  
vafa

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**Author:** ![amjjbonvin](https://dub1.discourse-cdn.com/flex013/user_avatar/ask.bioexcel.eu/amjjbonvin/32/23_2.png) [@amjjbonvin](https://ask.bioexcel.eu/u/amjjbonvin)\
**Post date:** [September 30, 2019, 7:21am UTC](https://ask.bioexcel.eu/t/no-correlation-between-score-and-binding-affinity/1699/2 "2019-09-30T07:21:32Z")

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• P. Kastritis and A.M.J.J. Bonvin Are scoring functions in protein-protein docking ready to predict interactomes? Clues from a novel binding affinity benchmark. J. Proteome Research, 9, 2216-2225 (2010). [https://doi.org/doi:10.1021/pr9009854](https://doi.org/doi:10.1021/pr9009854)

And related reviews:

• P.L. Kastritis and A.M.J.J. Bonvin Molecular origins of binding affinity: Seeking the Archimedean point. Curr. Opin. Struct. Biol., 23, 868-877 (2013).

• P.L. Kastritis and A.M.J.J. Bonvin On the binding affinity of macromolecular interactions: daring to ask why proteins interact J. R. Soc. Interface, 10, doi: 10.1098/rsif.2012.0835 (2013)

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**Author:** ![vafamayahi](https://avatars.discourse-cdn.com/v4/letter/v/f6c823/32.png) [@vafamayahi](https://ask.bioexcel.eu/u/vafamayahi)\
**Post date:** [September 30, 2019, 7:36am UTC](https://ask.bioexcel.eu/t/no-correlation-between-score-and-binding-affinity/1699/3 "2019-09-30T07:36:31Z")

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Thanks dear Dr. Bonvin.