# Interacting on unstructured region
**URL:** https://ask.bioexcel.eu/t/interacting-on-unstructured-region/2000
**Category:** HADDOCK
**Created:** [May 7, 2020, 7:58am UTC](https://ask.bioexcel.eu/t/interacting-on-unstructured-region/2000 "2020-05-07T07:58:09Z")
**Posts on this page:** 2
**Page:** 1
### Author:  [@skourtis](https://ask.bioexcel.eu/u/skourtis)
#### Post date: [May 7, 2020, 7:58am UTC](https://ask.bioexcel.eu/t/interacting-on-unstructured-region/2000/1 "2020-05-07T07:58:09Z")
Hi,
I have a two protein with their respective PDBs and I suspect that the bromo-binding domain of one binds onto the unstructured tail of the other. This unstructured tail of interest, is not part of the PDB. Can I still predict this interaction?
Thank you,
Savvas
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### Author:  [@amjjbonvin](https://ask.bioexcel.eu/u/amjjbonvin)
#### Post date: [May 7, 2020, 8:35am UTC](https://ask.bioexcel.eu/t/interacting-on-unstructured-region/2000/2 "2020-05-07T08:35:07Z")
No tail no interaction I would say…
And if the interaction is with the disordered tail, rather only model that part - no need to use the full protein. This is then a protein-peptide docking case
Relevant info for this scenario:
- C. Geng, S. Narasimhan, J. P.G.L.M. Rodrigues and A.M.J.J. Bonvin. [Information-driven, ensemble flexible peptide docking using HADDOCK](https://doi.org/10.1007/978-1-4939-6798-8_8). _Methods in Molecular Biology: Modeling Peptide-Protein Interactions._ Eds Ora Schueler-Furman and Nir London. Humana Press Inc. _1561_, 109-138 (2017).
- M. Trellet, A.S.J. Melquiond and A.M.J.J. Bonvin. [Information-driven modelling of protein-peptide complexes.](http://link.springer.com/protocol/10.1007/978-1-4939-2285-7_10) _Methods in Molecular Biology._ Ed. Peng Zhou. Humana Press Inc. 221-239 (2015)
- M. Trellet, A.S.J. Melquiond and A.M.J.J. Bonvin. [A Unified Conformational Selection and Induced Fit Approach to Protein-Peptide Docking](http://dx.plos.org/10.1371/journal.pone.0058769) _PLoS ONE_, _8(3)_ e58769 (2013).