# HADDOCK parameter problem

**URL:** <https://ask.bioexcel.eu/t/haddock-parameter-problem/1893>\
**Category:** Uncategorized\
**Created:** [April 10, 2020, 3:13am UTC](https://ask.bioexcel.eu/t/haddock-parameter-problem/1893 "2020-04-10T03:13:24Z")\
**Posts on this page:** 1\
**Page:** 1

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**Author:** ![1910452](https://avatars.discourse-cdn.com/v4/letter/1/6de8d8/32.png) [@1910452](https://ask.bioexcel.eu/u/1910452)\
**Post date:** [April 10, 2020, 3:13am UTC](https://ask.bioexcel.eu/t/haddock-parameter-problem/1893/1 "2020-04-10T03:13:24Z")

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Hello,

I want to know the total binding ability of two proteins, and I have read the parameters in the manual ([http://www.bonvinlab.org/software/haddock2.2/manual,http://www.bonvinlab.org/education](http://www.bonvinlab.org/software/haddock2.2/manual,http://www.bonvinlab.org/education))，I also read these two papers(Nature Protocol 2010 and JMB 2016).

I think this parameter represents the binding ability, _dEint_ :binding energy (Etotal complex - Sum[Etotal components,but we don’t have that parameter in our haddock results.

Here are our HADDOCK results, which parameter in our result represents the binding ability of the protein?

|HADDOCK score|-103.7 +/- 6.0|  
|Cluster size|5|  
|RMSD from the overall lowest-energy structure|1.2 +/- 1.0|  
|Van der Waals energy|-56.5 +/- 6.3|  
|Electrostatic energy|-172.8 +/- 25.0|  
|Desolvation energy|-13.9 +/- 3.8|  
|Restraints violation energy|12.2 +/- 12.9|  
|Buried Surface Area|1655.1 +/- 112.8|  
|Z-Score|-1.3|

Thanks,

Chang