# Finding the binding energy of a Protein\_DNA complex

**URL:** <https://ask.bioexcel.eu/t/finding-the-binding-energy-of-a-protein-dna-complex/1734>\
**Category:** Uncategorized\
**Created:** [October 22, 2019, 10:49am UTC](https://ask.bioexcel.eu/t/finding-the-binding-energy-of-a-protein-dna-complex/1734 "2019-10-22T10:49:23Z")\
**Posts on this page:** 3\
**Page:** 1

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**Author:** ![satya22](https://avatars.discourse-cdn.com/v4/letter/s/da6949/32.png) [@satya22](https://ask.bioexcel.eu/u/satya22)\
**Post date:** [October 22, 2019, 10:49am UTC](https://ask.bioexcel.eu/t/finding-the-binding-energy-of-a-protein-dna-complex/1734/1 "2019-10-22T10:49:24Z")

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Sir,  
I have docked my protein-dna complex by using HADDOCK server i want to see the Binding energy of each cluster that is generated by HADDOCK i saw prodigy have protein-protein and protein-ligand binding energy calculations are there but didnot find for protein-dna complex and how to calculate internal energy of the complex  
Can you please help me out with a high priority its urgent

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**Author:** ![amjjbonvin](https://dub1.discourse-cdn.com/flex013/user_avatar/ask.bioexcel.eu/amjjbonvin/32/23_2.png) [@amjjbonvin](https://ask.bioexcel.eu/u/amjjbonvin)\
**Post date:** [October 22, 2019, 5:56pm UTC](https://ask.bioexcel.eu/t/finding-the-binding-energy-of-a-protein-dna-complex/1734/2 "2019-10-22T17:56:57Z")

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We don’t have any tools that can predict the binding affinity of protein-DNA complexes, nor am I aware of any reliable tool.

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**Author:** ![attaribinm](https://avatars.discourse-cdn.com/v4/letter/a/87869e/32.png) [@attaribinm](https://ask.bioexcel.eu/u/attaribinm)\
**Post date:** [January 22, 2020, 6:49am UTC](https://ask.bioexcel.eu/t/finding-the-binding-energy-of-a-protein-dna-complex/1734/3 "2020-01-22T06:49:33Z")

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@satya22 Did you find any way to calculate binding affinity of Protein DNA complex?