# Failed error message
**URL:** https://ask.bioexcel.eu/t/failed-error-message/4086
**Category:** HADDOCK
**Created:** [January 29, 2023, 12:41pm UTC](https://ask.bioexcel.eu/t/failed-error-message/4086 "2023-01-29T12:41:15Z")
**Posts on this page:** 6
**Page:** 1
### Author:  [@halniss](https://ask.bioexcel.eu/u/halniss)
#### Post date: [January 29, 2023, 12:41pm UTC](https://ask.bioexcel.eu/t/failed-error-message/4086/1 "2023-01-29T12:41:15Z")
Dear Sir/Madam,
We sent a job on Haddock 2.4, but the run failed (see below). Can you please advise us regarding this error.
Thank you in advance
Best regards
Hasan Alniss
Job number: 206447
URL of the results page: [https://wenmr.science.uu.nl/haddock2.4/run/1577259249/206447-MGB28\_ACTA\_WR\_5](https://eur03.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwenmr.science.uu.nl%2Fhaddock2.4%2Frun%2F1577259249%2F206447-MGB28_ACTA_WR_5&data=05%7C01%7Chalniss%40sharjah.ac.ae%7Cdf33ffa365c94e606da608db01e49b92%7Ce0ba2eba54254d9bb24bf0f4845bcf62%7C0%7C0%7C638105853591745147%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=ISLRUwsxy1FVQAMD0by2pVNMt6XnrR%2FzPv0BKqp5dr8%3D&reserved=0)
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### Author:  [@amjjbonvin](https://ask.bioexcel.eu/u/amjjbonvin)
#### Post date: [January 30, 2023, 7:19pm UTC](https://ask.bioexcel.eu/t/failed-error-message/4086/2 "2023-01-30T19:19:55Z")
Hi Hasan
We found the origin of the problem but would like to see if you have edited some specific parameters in the web form related to the interaction matrix?
Did you change anything, or emptied may-be some fields?
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### Author:  [@amjjbonvin](https://ask.bioexcel.eu/u/amjjbonvin)
#### Post date: [January 31, 2023, 12:55pm UTC](https://ask.bioexcel.eu/t/failed-error-message/4086/3 "2023-01-31T12:55:51Z")
Actually we can not reproduce the problem. So any info about what you exactly did in setting up that run would help.
Looking at your data it seems like you used the refinement interface. If this is the case then your system runs fine in our hands:
[https://bianca.science.uu.nl/haddock2.4/run/1111111111/206916-test](https://bianca.science.uu.nl/haddock2.4/run/1111111111/206916-test)
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### Author:  [@amjjbonvin](https://ask.bioexcel.eu/u/amjjbonvin)
#### Post date: [January 31, 2023, 12:57pm UTC](https://ask.bioexcel.eu/t/failed-error-message/4086/4 "2023-01-31T12:57:04Z")
But the results look crap… Did you intend to turn off the interaction energy between the two ligands?
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### Author:  [@halniss](https://ask.bioexcel.eu/u/halniss)
#### Post date: [January 31, 2023, 1:24pm UTC](https://ask.bioexcel.eu/t/failed-error-message/4086/5 "2023-01-31T13:24:02Z")
Thank you for your response. I asked the research assistant who submitted the run and he said that he used the default settings and did not change anything. We are interested in finding out the interactions between the ligand dimer and DNA, not between the two ligands.
I tried myself to do structure refinement to the same complex and I got good results. The haddock score was - 213. I do not know what was the problem.
See the link below.
[https://bianca.science.uu.nl/haddock2.4/result/9694739213/206629-trial](https://bianca.science.uu.nl/haddock2.4/result/9694739213/206629-trial)
 Hasan Yaser Hasan Al Niss
**Associate professor**
College of Pharmacy
Medicinal Chemistry
**T:** +97165057427 **|** **E:** [halniss@sharjah.ac.ae](mailto:halniss@sharjah.ac.ae)
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### Author:  [@amjjbonvin](https://ask.bioexcel.eu/u/amjjbonvin)
#### Post date: [January 31, 2023, 1:35pm UTC](https://ask.bioexcel.eu/t/failed-error-message/4086/6 "2023-01-31T13:35:35Z")
Well - since we can not reproduce the error I guess we can close this one.