#  docking of proteins and nucleic acids

**URL:** <https://ask.bioexcel.eu/t/docking-of-proteins-and-nucleic-acids/5649>\
**Category:** HADDOCK\
**Created:** [May 5, 2025, 8:30am UTC](https://ask.bioexcel.eu/t/docking-of-proteins-and-nucleic-acids/5649 "2025-05-05T08:30:54Z")\
**Posts on this page:** 2\
**Page:** 1

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**Author:** ![Lixiaorong](https://avatars.discourse-cdn.com/v4/letter/l/c68b51/32.png) [@Lixiaorong](https://ask.bioexcel.eu/u/Lixiaorong)\
**Post date:** [May 5, 2025, 8:30am UTC](https://ask.bioexcel.eu/t/docking-of-proteins-and-nucleic-acids/5649/1 "2025-05-05T08:30:54Z")

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How to perform blind docking of proteins and nucleic acids

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**Author:** ![marco.giulini](https://dub1.discourse-cdn.com/flex013/user_avatar/ask.bioexcel.eu/marco.giulini/32/961_2.png) [@marco.giulini](https://ask.bioexcel.eu/u/marco.giulini)\
**Post date:** [May 5, 2025, 8:49am UTC](https://ask.bioexcel.eu/t/docking-of-proteins-and-nucleic-acids/5649/2 "2025-05-05T08:49:12Z")

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You can use the ab-initio mode in the HADDOCK2.4 webserver.

PS: the forum is searchable, you can find a lot of information about protein-DNA docking and ab-initio (blind) docking, as for example this thread [Metrics for the Evaluation of Docking Model Quality - #5 by pei](https://ask.bioexcel.eu/t/metrics-for-the-evaluation-of-docking-model-quality/4294/5)

PS2: You can find an additional tutorial for protein-DNA docking using HADDOCK 2.4 here [Protein-DNA docking Using HADDOCK High-Ambiguity Driven DOCKing – Bonvin Lab](https://www.bonvinlab.org/education/HADDOCK24/HADDOCK24-protein-DNA-basic/)