# Docked pose selection

**URL:** <https://ask.bioexcel.eu/t/docked-pose-selection/659>\
**Category:** HADDOCK\
**Created:** [December 5, 2017, 9:23am UTC](https://ask.bioexcel.eu/t/docked-pose-selection/659 "2017-12-05T09:23:23Z")\
**Posts on this page:** 2\
**Page:** 1

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**Author:** ![William\_Chong](https://avatars.discourse-cdn.com/v4/letter/w/b77776/32.png) [@William\_Chong](https://ask.bioexcel.eu/u/William_Chong)\
**Post date:** [December 5, 2017, 9:23am UTC](https://ask.bioexcel.eu/t/docked-pose-selection/659/1 "2017-12-05T09:23:23Z")

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for some docking cases, the top cluster size is rather small (10) compared to the second cluster (128). The difference of z-score (-1.2 and -1.1) is not significant, however the RMSD deviated a lot (0.6 and 12.7). In such a case, would it be fine if we proceed with the top cluster? or we should consider the docked pose from the second class?

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**Author:** ![amjjbonvin](https://dub1.discourse-cdn.com/flex013/user_avatar/ask.bioexcel.eu/amjjbonvin/32/23_2.png) [@amjjbonvin](https://ask.bioexcel.eu/u/amjjbonvin)\
**Post date:** [December 5, 2017, 10:09am UTC](https://ask.bioexcel.eu/t/docked-pose-selection/659/2 "2017-12-05T10:09:33Z")

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The large RMSD differences indicate the two clusters represent different solution. I would carefully examine both…