# Dock ligand 1ot7 to Farnesoid X nuclear receptor (FXR)

**URL:** https://ask.bioexcel.eu/t/dock-ligand-1ot7-to-farnesoid-x-nuclear-receptor-fxr/853
**Category:** HADDOCK
**Created:** [March 21, 2018, 11:01pm UTC](https://ask.bioexcel.eu/t/dock-ligand-1ot7-to-farnesoid-x-nuclear-receptor-fxr/853 "2018-03-21T23:01:52Z")
**Posts on this page:** 2
**Page:** 1

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### Author: ![Athanasios](https://avatars.discourse-cdn.com/v4/letter/a/779978/32.png) [@Athanasios](https://ask.bioexcel.eu/u/Athanasios)
#### Post date: [March 21, 2018, 11:01pm UTC](https://ask.bioexcel.eu/t/dock-ligand-1ot7-to-farnesoid-x-nuclear-receptor-fxr/853/1 "2018-03-21T23:01:52Z")

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Which are the active residues in order to setup the HADDOCK server properly?

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### Author: ![joaor](https://dub1.discourse-cdn.com/flex013/user_avatar/ask.bioexcel.eu/joaor/32/194_2.png) [@joaor](https://ask.bioexcel.eu/u/joaor)
#### Post date: [March 21, 2018, 11:15pm UTC](https://ask.bioexcel.eu/t/dock-ligand-1ot7-to-farnesoid-x-nuclear-receptor-fxr/853/2 "2018-03-21T23:15:23Z")

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Have a look at our tutorial: [http://www.bonvinlab.org/education/HADDOCK-binding-sites/](http://www.bonvinlab.org/education/HADDOCK-binding-sites/)

In short, the ligand is usually defined as active and the pocket of the receptor as active/passive in it0/it1 & water, respectively. The pocket itself depends, it’s up to you to define.