# Different results on Intel/AMD machines **URL:** \ **Category:** HADDOCK\ **Created:** [July 19, 2022, 2:34am UTC](https://ask.bioexcel.eu/t/different-results-on-intel-amd-machines/3814 "2022-07-19T02:34:28Z")\ **Posts on this page:** 6\ **Page:** 1
**Author:** ![unmerged](https://avatars.discourse-cdn.com/v4/letter/u/dc4da7/32.png) [@unmerged](https://ask.bioexcel.eu/u/unmerged)\ **Post date:** [July 19, 2022, 2:34am UTC](https://ask.bioexcel.eu/t/different-results-on-intel-amd-machines/3814/1 "2022-07-19T02:34:28Z")
I’m getting different results from running examples/docking-protein-protein/docking-protein-protein-test.cfg command to run ```auto cd examples/docking-protein-protein haddock3 docking-protein-protein-test.cfg ``` amd’s run1-test/7\_caprieval/capri\_ss.tsv ```auto model md5 caprieval_rank score irmsd fnat lrmsd ilrmsd dockq cluster-id cluster-ranking self.model-cluster-ranking ../6_emref/emref_1.pdb - 1 -110.599 9.146 0.111 17.011 15.393 0.112 - - - ../6_emref/emref_2.pdb - 2 -105.002 2.145 0.556 3.893 3.476 0.570 - - - ../6_emref/emref_3.pdb - 3 -88.291 9.267 0.111 16.617 13.212 0.115 - - - ../6_emref/emref_4.pdb - 4 -81.664 11.176 0.139 18.428 18.058 0.111 - - - ../6_emref/emref_5.pdb - 5 -74.947 11.047 0.111 18.039 17.959 0.104 - - - ``` intel’s ```auto model md5 caprieval_rank score irmsd fnat lrmsd ilrmsd dockq cluster-id cluster-ranking self.model-cluster-ranking ../6_emref/emref_1.pdb - 1 -110.232 1.450 0.694 2.915 2.326 0.702 - - - ../6_emref/emref_2.pdb - 2 -92.448 2.680 0.500 5.157 4.130 0.490 - - - ../6_emref/emref_5.pdb - 3 -92.102 10.946 0.028 19.065 19.475 0.071 - - - ../6_emref/emref_3.pdb - 4 -74.786 10.115 0.028 16.993 15.180 0.083 - - - ../6_emref/emref_4.pdb - 5 -72.464 3.774 0.222 6.956 5.266 0.319 - - - ``` other info: 1、both using haddock3 git commit 0dad275 2、same CNS binary (compiled on Intel machine and then copied to AMD) 3、both with Ubuntu 22.04 4、CPU: ```auto cat /proc/cpuinfo | grep 'name'| uniq model name : 11th Gen Intel(R) Core(TM) i7-11700 @ 2.50GHz model name : AMD EPYC 7532 32-Core Processor ``` 5、in 0\_topoaa folder, \*.inp are exactly same, \*.psf files are the same except for the one line telling date of output 6、I’m getting slightly different \_haddock.pdb files in 0\_topoaa folder as following (left is Intel) ![截屏2022-07-19 10.32.54](https://europe1.discourse-cdn.com/flex013/uploads/bioexcel/original/1X/4a76f79b7ad7886c3616dad17e76bfbdd5b75011.png) ---
**Author:** ![amjjbonvin](https://dub1.discourse-cdn.com/flex013/user_avatar/ask.bioexcel.eu/amjjbonvin/32/23_2.png) [@amjjbonvin](https://ask.bioexcel.eu/u/amjjbonvin)\ **Post date:** [July 19, 2022, 8:33am UTC](https://ask.bioexcel.eu/t/different-results-on-intel-amd-machines/3814/2 "2022-07-19T08:33:17Z")
You can not get exactly the same results when running on different hardware. This is the nature of the computations which is chaotic. Full reproducibility is only achievable on the same hardware. ---
**Author:** ![amjjbonvin](https://dub1.discourse-cdn.com/flex013/user_avatar/ask.bioexcel.eu/amjjbonvin/32/23_2.png) [@amjjbonvin](https://ask.bioexcel.eu/u/amjjbonvin)\ **Post date:** [July 19, 2022, 9:48am UTC](https://ask.bioexcel.eu/t/different-results-on-intel-amd-machines/3814/3 "2022-07-19T09:48:31Z")
PS: To compare two hardware, better to perform a full run to see if the results are consistent (but won’t be exactly the same). ---
**Author:** ![unmerged](https://avatars.discourse-cdn.com/v4/letter/u/dc4da7/32.png) [@unmerged](https://ask.bioexcel.eu/u/unmerged)\ **Post date:** [July 19, 2022, 3:44pm UTC](https://ask.bioexcel.eu/t/different-results-on-intel-amd-machines/3814/4 "2022-07-19T15:44:05Z")
Thanks for the reply. I tried haddocking with docking-protein-protein-full.cfg on three setups (local) setup1: 11th Gen Intel(R) Core™ i7-11700 @ 2.50GHz setup2: Intel(R) Core™ i9-10900 CPU @ 2.80GHz setup3: AMD EPYC 7532 32-Core Processor and here’s what I found: setup1 and setup2 output exactly the same 08\_caprieval/capri\_ss.tsv, down to last digits: ```auto model md5 caprieval_rank score irmsd fnat lrmsd ilrmsd dockq cluster-id cluster-ranking self.model-cluster-ranking ../07_emref/emref_32.pdb - 1 -133.753 2.090 0.694 3.979 3.088 0.618 - - - ../07_emref/emref_7.pdb - 2 -123.898 1.901 0.694 3.476 2.849 0.645 - - - ../07_emref/emref_20.pdb - 3 -120.499 0.973 0.833 1.497 1.226 0.836 - - - ../07_emref/emref_44.pdb - 4 -119.955 0.917 0.889 1.527 1.416 0.862 - - - ../07_emref/emref_78.pdb - 5 -119.565 0.969 0.889 1.504 1.319 0.855 - - - ../07_emref/emref_117.pdb - 6 -117.615 10.917 0.139 18.054 18.025 0.113 - - - ../07_emref/emref_26.pdb - 7 -117.032 1.693 0.639 2.813 2.158 0.660 - - - ../07_emref/emref_8.pdb - 8 -116.344 2.552 0.500 4.728 3.784 0.507 - - - ../07_emref/emref_89.pdb - 9 -115.889 2.445 0.444 4.823 3.066 0.491 - - - ``` meanwhile setup3 gives quite different top scores and ranking. ```auto ../07_emref/emref_8.pdb - 1 -126.115 1.949 0.722 3.876 2.855 0.641 - - - ../07_emref/emref_75.pdb - 2 -120.761 1.454 0.750 2.981 2.533 0.719 - - - ../07_emref/emref_4.pdb - 3 -120.174 1.635 0.722 2.843 2.385 0.693 - - - ../07_emref/emref_1.pdb - 4 -117.396 1.371 0.806 2.257 2.011 0.762 - - - ../07_emref/emref_3.pdb - 5 -116.627 2.612 0.528 4.944 4.049 0.508 - - - ../07_emref/emref_5.pdb - 6 -114.115 3.834 0.444 7.359 5.301 0.383 - - - ../07_emref/emref_57.pdb - 7 -113.359 1.625 0.639 2.678 2.271 0.670 - - - ../07_emref/emref_6.pdb - 8 -113.011 2.385 0.500 4.399 3.596 0.524 - - - ../07_emref/emref_65.pdb - 9 -111.223 0.967 0.889 1.818 1.512 0.851 - - - ``` Thus it’s possible two machines, for example setup1/2 using Intel architectures, generate same results (which I would rather prefer), and the difference between AMD and Intel CPUs is not insignificant. Furthermore, when running jobs on a cluster, they may be distributed to different architectures so output scores and structures would change from run to run, which makes reproducing results difficult. ---
**Author:** ![honoratorv](https://dub1.discourse-cdn.com/flex013/user_avatar/ask.bioexcel.eu/honoratorv/32/672_2.png) [@honoratorv](https://ask.bioexcel.eu/u/honoratorv)\ **Post date:** [July 19, 2022, 4:58pm UTC](https://ask.bioexcel.eu/t/different-results-on-intel-amd-machines/3814/5 "2022-07-19T16:58:55Z")
Thanks for this detailed explanation, could you please check if the models `../07_emref/emref_32.pdb` from setup1/2 is the same as `../07_emref/emref_8.pdb` from setup3? also @unmerged please remember that haddock3 in its current state is still very experimental and has not been tested/benchmarked and is _not recomended_ for production. Please refer to the current production version HADDOCK2.4 ---
**Author:** ![amjjbonvin](https://dub1.discourse-cdn.com/flex013/user_avatar/ask.bioexcel.eu/amjjbonvin/32/23_2.png) [@amjjbonvin](https://ask.bioexcel.eu/u/amjjbonvin)\ **Post date:** [July 19, 2022, 6:28pm UTC](https://ask.bioexcel.eu/t/different-results-on-intel-amd-machines/3814/6 "2022-07-19T18:28:39Z")
Interesting Although the scores are different, the quality of the models is quite similar. Did you check the cluster stats as well?