Really try first the server. Once you have a successful run (you are doing something wrong - not the server).
HaddockValidationError: You manually defined passive residues, but also that they should be determined automatically
Correct that error and try again. You can download all results and save them as long as you wish for on your computer.
Did you check your CNS installation. Can you start CNS manually?
For example, in my installation, I would have under
tcsh to first source the
Then I can type
cns and if your installation is successful you then see something that should resemble:
| Crystallography & NMR System (CNS) |
| CNSsolve |
Version: 1.3 at patch level U
Status: Special UU release with Rg, paramagnetic
and Z-restraints (A. Bonvin, UU 2013)
Written by: A.T.Brunger, P.D.Adams, G.M.Clore, W.L.DeLano,
J.Kuszewski, M.Nilges, N.S.Pannu, R.J.Read,
L.M.Rice, G.F.Schroeder, T.Simonson, G.L.Warren.
Copyright (c) 1997-2010 Yale University
Running on machine: Goodwine-3.local (Mac/Intel,64-bit)
Program started by: abonvin
Program started at: 07:57:44 on 15-Dec-2017
FFT3C: Using FFTPACK4.1
One this is working, you can then try running first one of the provided examples.
A protocol for running a local version of HADDOCK can be found in:
J.P.G.L.M Rodrigues, E. Karaca and A.M.J.J. Bonvin. Information-driven structural modelling of protein-protein interactions. Methods in Molecular Biology: Molecular Modelling of Proteins. Ed. Andreas Kokul. Humana Press Inc. 399-424 (2015).
And this forum is searchable - try first to look for answers. There are multiple threads about CNS problems, e.g.